Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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Tracheal bronchus (pig bronchus)
Tracheal bronchus (pig bronchus)

After writing an article on the tracheal bronchus, I was asked to describe the anatomy of the pig (Sus scrofa domesticus) lung and a comparison with the human lung. The function and general structure of the pig lung is similar to the human. Anatomy-wise... there are several differences.

It is important to understand that directional terminology used to describe the anatomy of the pig is different than that used for the human. We use the anatomical position for humans, but as the pig is a quadruped, there is no such position for the pig, and veterinary terminology is used.. For further information on this topic, click here.

Following are two images. The first one is an anterior view of the human lungs and their tracheobronchial tree. The second image shows a ventral view of the pig tracheobronchial tree and both lungs.

Anterior view of the human lungs and tracheobronchial treeAnterior view of the human lungs and tracheobronchial tree

Pig lungs, ventral viewVentral view of the pig lungs and tracheobronchial tree

The first difference with the human lung is that there are two cardiac notches, right and left (the left cardiac notch is larger) whereas the human has only one, on the left lung.

The structure of the tracheobronchial tree in both species is similar, with incomplete cartilaginous rings and a posterior (dorsal) membrane that closes both the trachea and bronchi. Similarly, as the bronchial tree is more distal, the cartilaginous rings break up.

The trachea in the human ranges between 10 to 12 centimeters, while in the pig the trachea is longer, between 25 to 30 centimeters. Both bifurcate at the carina into a right and left main stem bronchus. In both species there is a large number of lymphatic nodes at the tracheal bifurcation (carinal nodes) which drain the lungs.

In the pig, the bronchus for the right cranial lobe arises directly from the trachea, and is known as the "tracheal bronchus". This does not normally happen in the human, and when it does it is considered an anatomical variation called a "pig bronchus", "bronchus suis", or "tracheal bronchus", and it can cause serious problems during intubation in surgery.

In the human, there are normally three lobes on the right side (upper, middle, and lower), and two on the left side (upper and lower). Each lobe has its separate lobar bronchus.

The right lung in the pig has 4 lobes: Cranial, middle, caudal, and an accessory lobe that is ventral and is located in the midline. Each lobe has its own separate lobar bronchus.

The left lung in the pig has two lobes: Cranial and caudal. The left cardiac notch splits the cranial lobe in two segments, but since these segments arise from a common bronchus, they are considered one lobe.

Sources:
1. "Essentials of Pig Anatomy" Sack, W.O.; Horowitz, A. 1982 Veterninary Textbooks, Ithaca, New York..
2. “Bronchial tree, lobular division and blood vessels of the pig lung” Nakakuki, S. J Vet Med Sci. 1994 Aug;56(4):685-9. 
3. “Bronchial anatomy and single-lung ventilation in the pig” Muton, WG. Can J Anesth 1999 46:7 p701-703

- Human tracheal bronchus endoscopic image modified from the original. Public domain.
- Anterior view of the human lungs and tracheobronchial tree image by . Patrick J. Lynch, medical illustrator, CC BY 2.5 <https://creativecommons.org/licenses/by/2.5>, via Wikimedia Commons.
- Ventral view of the Ventral view of the pig lungs and tracheobronchial tree image by Dr. Miranda, modified from the original. Public domain.